Comparative CRISPR type III-based knockdown of essential genes in hyperthermophilic Sulfolobales and the evasion of lethal gene silencing

CRISPR type III systems, which are abundantly found in archaea, recognize and degrade RNA in their specific response to invading nucleic acids. Therefore, these systems can be harnessed for gene knockdown technologies even in hyperthermophilic archaea to study essential genes. We show here the broad...

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Publicat a:RNA Biol
Autors principals: Zink, Isabelle Anna, Fouqueau, Thomas, Tarrason Risa, Gabriel, Werner, Finn, Baum, Buzz, Bläsi, Udo, Schleper, Christa
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951960/
https://ncbi.nlm.nih.gov/pubmed/32957821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2020.1813411
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