LncRNA H19 Alleviates Muscular Dystrophy Through Stabilizing Dystrophin

Dystrophin proteomic regulation in Muscular Dystrophies (MD) remains unclear. We report that a long noncoding RNA (lncRNA), H19, associates with dystrophin and inhibits E3 ligase-dependent poly-ubiquitination at Lys3584 (referred to as Ub-DMD) and its subsequent protein degradation. In-frame deletio...

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Foilsithe in:Nat Cell Biol
Main Authors: Zhang, Yaohua, Li, Yajuan, Hu, Qingsong, Xi, Yutao, Xing, Zhen, Zhang, Zhao, Huang, Lisa, Wu, Jianbo, Liang, Ke, Nguyen, Tina K., Egranov, Sergey D., Sun, Chengcao, Zhao, Zilong, Hawke, David H., Li, Jin, Sun, Deqiang, Kim, Jean J., Zhang, Ping, Cheng, Jie, Farida, Abid, Hung, Mien-Chie, Han, Leng, Darabi, Radbod, Lin, Chunru, Yang, Liuqing
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951180/
https://ncbi.nlm.nih.gov/pubmed/33106653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00595-5
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