CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract

Ultraviolet B (UVB) irradiation could trigger DNA double-strand breaks (DDSBs) and senescence in lens epithelial cells (LECs), thus inducing age-related cortical cataract (ARCC) formation. Cell-cycle irreversible arrest induced by DDSBs depended on excessive activation of ataxia-telangiectasia mutat...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Liu, Junliang, Zhang, Jinling, Zhang, Guowei, Zhou, Tianqiu, Zou, Xi, Guan, Huaijin, Wang, Yong
Format: Artigo
Language:Inglês
Published: Impact Journals 2021
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7950295/
https://ncbi.nlm.nih.gov/pubmed/33508783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202470
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