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Thermal Proteome Profiling in Zebrafish Reveals Effects of Napabucasin on Retinoic Acid Metabolism

Thermal proteome profiling (TPP) allows for the unbiased detection of drug–target protein engagements in vivo. Traditionally, 1 cell type is used for TPP studies, with the risk of missing important differentially expressed target proteins. The use of whole organisms would circumvent this problem. Ze...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Leijten, Niels M., Bakker, Petra, Spaink, Herman P., den Hertog, Jeroen, Lemeer, Simone
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7950114/
https://ncbi.nlm.nih.gov/pubmed/33594990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.002273
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