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Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis

Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones. Many characterized Tg gene mutations produce secretion-defective variants resulting in congenital hypothyroidism. Tg processing and secretion is controlled by extensive interaction...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Wright, Madison T., Kouba, Logan, Plate, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7950113/
https://ncbi.nlm.nih.gov/pubmed/33581410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.002168
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