Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis

The serine protease inhibitor Kazal type 1 (SPINK1) protects the pancreas from intrapancreatic trypsin activation that can lead to pancreatitis. Loss-of-function genetic variants of SPINK1 increase the risk for chronic pancreatitis, often by diminishing inhibitor expression or secretion. Variants th...

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Vydáno v:J Biol Chem
Hlavní autoři: Szabó, András, Toldi, Vanda, Gazda, Lívia Diána, Demcsák, Alexandra, Tőzsér, József, Sahin-Tóth, Miklós
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949130/
https://ncbi.nlm.nih.gov/pubmed/33515547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100343
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