Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target

Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 (HK2) in many cancers and its limited expression in normal tissues make it a...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Ferreira, Juliana C., Khrbtli, Abdul-Rahman, Shetler, Cameron L., Mansoor, Samman, Ali, Liaqat, Sensoy, Ozge, Rabeh, Wael M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949118/
https://ncbi.nlm.nih.gov/pubmed/33187984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015293
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