Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes

Activation of energy-dissipating brown/beige adipocytes represents an attractive therapeutic strategy against metabolic disorders. While lactate is known to induce beiging through the regulation of Ucp1 gene expression, the role of lactate transporters on beige adipocytes' ongoing metabolic act...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Lagarde, Damien, Jeanson, Yannick, Barreau, Corinne, Moro, Cedric, Peyriga, Lindsay, Cahoreau, Edern, Guissard, Christophe, Arnaud, Emmanuelle, Galinier, Anne, Bouzier-Sore, Anne-Karine, Pellerin, Luc, Chouchani, Edward T., Pénicaud, Luc, Ader, Isabelle, Portais, Jean-Charles, Casteilla, Louis, Carrière, Audrey
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949083/
https://ncbi.nlm.nih.gov/pubmed/33268383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016303
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