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T cell receptor–dependent S-acylation of ZAP-70 controls activation of T cells
ZAP-70 is a tyrosine kinase essential for T cell immune responses. Upon engagement of the T cell receptor (TCR), ZAP-70 is recruited to the specialized plasma membrane domains, becomes activated, and is released to phosphorylate its laterally segregated targets. A shift in ZAP-70 distribution at the...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7949058/ https://ncbi.nlm.nih.gov/pubmed/33482200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100311 |
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