The cytoplasmic domain of the AAA+ protease FtsH is tilted with respect to the membrane to facilitate substrate entry

AAA+ proteases are degradation machines that use ATP hydrolysis to unfold protein substrates and translocate them through a central pore toward a degradation chamber. FtsH, a bacterial membrane-anchored AAA+ protease, plays a vital role in membrane protein quality control. How substrates reach the F...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Carvalho, Vanessa, Prabudiansyah, Irfan, Kovacik, Lubomir, Chami, Mohamed, Kieffer, Roland, van der Valk, Ramon, de Lange, Nick, Engel, Andreas, Aubin-Tam, Marie-Eve
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949044/
https://ncbi.nlm.nih.gov/pubmed/33154162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014739
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