4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts

Osteogenesis imperfecta (OI) is a heritable brittle bone disease mainly caused by mutations in the two type I collagen genes. Collagen synthesis is a complex process including trimer formation, glycosylation, secretion, extracellular matrix (ECM) formation, and mineralization. Using OI patient-deriv...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Takeyari, Shinji, Kubota, Takuo, Ohata, Yasuhisa, Fujiwara, Makoto, Kitaoka, Taichi, Taga, Yuki, Mizuno, Kazunori, Ozono, Keiichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948972/
https://ncbi.nlm.nih.gov/pubmed/33154166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014709
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