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The antiretroviral 2′,3′-dideoxycytidine causes mitochondrial dysfunction in proliferating and differentiated HepaRG human cell cultures

Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus infection, and their use can cause mitochondrial toxicity, including mitochondrial DNA (mtDNA) depletion in several cases. The first-generation NRTIs, including 2′,3′-dideoxycytidine (...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Young, Carolyn K.J., Wheeler, Joel H., Rahman, Md. Mostafijur, Young, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948951/
https://ncbi.nlm.nih.gov/pubmed/33334881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014885
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