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PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain
Hsp70 proteins are a family of ancient and conserved chaperones. They play important roles in vital cellular processes, such as protein quality control and the stress response. Hsp70 proteins are a potential drug target for treatment of disease, particularly cancer. PES (2-phenylethynesulfonamide or...
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| Pubblicato in: | J Biol Chem |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7948744/ https://ncbi.nlm.nih.gov/pubmed/33835030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015440 |
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