The β6/β7 region of the Hsp70 substrate-binding domain mediates heat-shock response and prion propagation

Hsp70 is a highly conserved chaperone that in addition to providing essential cellular functions and aiding in cell survival following exposure to a variety of stresses is also a key modulator of prion propagation. Hsp70 is composed of a nucleotide-binding domain (NBD) and substrate-binding domain (...

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Veröffentlicht in:Cell Mol Life Sci
Hauptverfasser: Xu, Linan, Gong, Weibin, Cusack, Sarah A., Wu, Huiwen, Loovers, Harriët M., Zhang, Hong, Perrett, Sarah, Jones, Gary W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852193/
https://ncbi.nlm.nih.gov/pubmed/29124308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2698-3
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