A vicious cycle of bisretinoid formation and oxidation relevant to recessive Stargardt disease

The ability of iron to transfer electrons enables the contribution of this metal to a variety of cellular activities even as the redox properties of iron are also responsible for the generation of hydroxyl radicals ((•)OH), the most destructive of the reactive oxygen species. We previously showed th...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Zhao, Jin, Kim, Hye Jin, Ueda, Keiko, Zhang, Kevin, Montenegro, Diego, Dunaief, Joshua L., Sparrow, Janet R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948646/
https://ncbi.nlm.nih.gov/pubmed/33837742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100259
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