Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis

Lipids in complex, protein-enriched films at air/liquid interfaces reduce surface tension. In the absence of this benefit, the light refracting and immunoprotective tear film on eyes would collapse. Premature collapse, coupled with chronic inflammation compromising visual acuity, is a hallmark of dr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Georgiev, Georgi A., Gh., Mohammad Sharifian, Romano, Jeff, Dias Teixeira, Karina L., Struble, Craig, Ryan, Denise S., Sia, Rose K., Kitt, Jay P., Harris, Joel M., Hsu, Ku-Lung, Libby, Adam, Odrich, Marc G., Suárez, Tatiana, McKown, Robert L., Laurie, Gordon W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948570/
https://ncbi.nlm.nih.gov/pubmed/33187980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015833
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