A cell competition–based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation

Breakpoint Cluster Region-Abelson kinase (BCR–Abl) is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. Although tyrosine kinase inhibitors provide an effective treatment for these diseases, they generally do not kill leukemic stem cells (LSCs), the can...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Tadele, Dagim Shiferaw, Robertson, Joseph, Crispin, Richard, Herrera, Maria C., Chlubnová, Markéta, Piechaczyk, Laure, Ayuda-Durán, Pilar, Singh, Sachin Kumar, Gedde-Dahl, Tobias, Fløisand, Yngvar, Skavland, Jørn, Wesche, Jørgen, Gjertsen, Bjørn-Tore, Enserink, Jorrit M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2020
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948465/
https://ncbi.nlm.nih.gov/pubmed/33303632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015285
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन