A BCMAxCD3 bispecific T cell–engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells

CD3-engaging bispecific antibodies (bsAbs) and chimeric antigen receptor (CAR) T cells are potent therapeutic approaches for redirecting patient T cells to recognize and kill tumors. Here we describe a fully human bsAb (REGN5458) that binds to B-cell maturation antigen (BCMA) and CD3, and compare it...

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: DiLillo, David J., Olson, Kara, Mohrs, Katja, Meagher, Thomas Craig, Bray, Kevin, Sineshchekova, Olga, Startz, Thomas, Kuhnert, Jessica, Retter, Marc W., Godin, Stephen, Sharma, Prachi, Delfino, Frank, Lin, John, Smith, Eric, Thurston, Gavin, Kirshner, Jessica R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2021
Fag:
Immunobiology and Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948265/
https://ncbi.nlm.nih.gov/pubmed/33651100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002736
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