Increased Burden of Rare Sequence Variants in GnRH-Associated Genes in Women With Hypothalamic Amenorrhea

CONTEXT: Functional hypothalamic amenorrhea (HA) is a common, acquired form of hypogonadotropic hypogonadism that occurs in the setting of energy deficits and/or stress. Variability in individual susceptibility to these stressors, HA heritability, and previous identification of several rare sequence...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Delaney, Angela, Burkholder, Adam B, Lavender, Christopher A, Plummer, Lacey, Mericq, Veronica, Merino, Paulina M, Quinton, Richard, Lewis, Katie L, Meader, Brooke N, Albano, Alessandro, Shaw, Natalie D, Welt, Corrine K, Martin, Kathryn A, Seminara, Stephanie B, Biesecker, Leslie G, Bailey-Wilson, Joan E, Hall, Janet E
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Clinical Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7947783/
https://ncbi.nlm.nih.gov/pubmed/32870266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/clinem/dgaa609
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