ESR1 Mutations Associated With Estrogen Insensitivity Syndrome Change Conformation of Ligand-Receptor Complex and Altered Transcriptome Profile

Estrogen insensitivity syndrome (EIS) arises from rare mutations in estrogen receptor-α (ERα, encoded by ESR1 gene) resulting in the inability of estrogen to exert its biological effects. Due to its rarity, mutations in ESR1 gene and the underlying molecular mechanisms of EIS have not been thoroughl...

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Bibliografiske detaljer
Udgivet i:Endocrinology
Main Authors: Li, Yin, Hamilton, Katherine J, Perera, Lalith, Wang, Tianyuan, Gruzdev, Artiom, Jefferson, Tanner B, Zhang, Austin X, Mathura, Emilie, Gerrish, Kevin E, Wharey, Laura, Martin, Negin P, Li, Jian-Liang, Korach, Kenneth S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7947601/
https://ncbi.nlm.nih.gov/pubmed/32242619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqaa050
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