Curcumin Acts as a Positive Allosteric Modulator of α(7)-Nicotinic Acetylcholine Receptors and Reverses Nociception in Mouse Models of Inflammatory Pain

Effects of curcumin, a major ingredient of turmeric, were tested on the function of the α(7)-subunit of the human nicotinic acetylcholine (α(7)-nACh) receptor expressed in Xenopus oocytes and on nociception in mouse models of tonic and visceral pain. Curcumin caused a significant potentiation of cur...

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Dades bibliogràfiques
Publicat a:J Pharmacol Exp Ther
Autors principals: El Nebrisi, Eslam Gaber, Bagdas, Deniz, Toma, Wisam, Al Samri, Halima, Brodzik, Anna, Alkhlaif, Yasmin, Yang, Keun-Hang Susan, Howarth, Frank Christopher, Damaj, Imad M., Oz, Murat
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2018
Matèries:
Neuropharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7947331/
https://ncbi.nlm.nih.gov/pubmed/29339457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.245068
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