Induction of Therapeutic Protection in an HPV16-Associated Mouse Tumor Model Through Targeting the Human Papillomavirus-16 E5 Protein to Dendritic Cells

HPV E5 is an oncoprotein mainly expressed in premalignant lesions, which makes it an important target for a vaccine to prevent or cure cervical cancer (CC). In this study, we evaluated whether E5 targeted to DEC-205, present in dendritic cells (DCs), could induce a therapeutic protection against HPV...

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Publicat a:Front Immunol
Autors principals: Badillo-Godinez, Oscar, Pedroza-Saavedra, Adolfo, Valverde-Garduño, Veronica, Bermudez-Morales, Victor, Maldonado-Gama, Minerva, Leon-Letelier, Ricardo, Bonifaz, Laura C., Esquivel-Guadarrama, Fernando, Gutierrez-Xicotencatl, Lourdes
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7947241/
https://ncbi.nlm.nih.gov/pubmed/33717073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.593161
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