PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling

Oral squamous cell carcinoma (OSCC) has a high incidence of metastasis. Tumour immunotherapy targeting PD-L1 or PD-1 has been revolutionary; however, only a few patients with OSCC respond to this treatment. Therefore, it is essential to gain insights into the molecular mechanisms underlying the grow...

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Vydáno v:Int J Oral Sci
Hlavní autoři: Cui, Bomiao, Chen, Jiao, Luo, Min, Liu, Yiying, Chen, Hongli, Lü, Die, Wang, Liwei, Kang, Yingzhu, Feng, Yun, Huang, Libin, Zhang, Ping
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946959/
https://ncbi.nlm.nih.gov/pubmed/33692335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41368-021-00112-w
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