Identification of an alpha-1 antitrypsin variant with enhanced specificity for factor XIa by phage display, bacterial expression, and combinatorial mutagenesis

Coagulation Factor XIa (FXIa) is an emerging target for antithrombotic agent development. The M358R variant of the serpin alpha-1 antitrypsin (AAT) inhibits both FXIa and other proteases. Our aim was to enhance the specificity of AAT M358R for FXIa. We randomized two AAT M358R phage display librarie...

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Publicado no:Sci Rep
Main Authors: Bhakta, Varsha, Hamada, Mostafa, Nouanesengsy, Amy, Lapierre, Jessica, Perruzza, Darian L., Sheffield, William P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946950/
https://ncbi.nlm.nih.gov/pubmed/33692375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84618-7
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