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Self and microbiota-derived epitopes induce CD4(+) T cell anergy and conversion into CD4(+)Foxp3(+) regulatory cells
The physiological role of T cell anergy induction as a key mechanism supporting self-tolerance remains undefined, and natural antigens that induce anergy are largely unknown. In this report, we used TCR sequencing to show that the recruitment of CD4(+)CD44(+)Foxp3(−)CD73(+)FR4(+) anergic (Tan) cells...
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| Pubblicato in: | Mucosal Immunol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group US
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7946630/ https://ncbi.nlm.nih.gov/pubmed/33139845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-020-00349-4 |
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