TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients

Accumulating evidence indicates that immune checkpoint inhibitors (ICIs) can restore CD8(+) cytotoxic T lymphocyte (CTL) functions in preclinical models of acute myeloid leukemia (AML). However, ICIs targeting programmed cell death 1 (PDCD1, best known as PD-1) and cytotoxic T lymphocyte-associated...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Rakova, Jana, Truxova, Iva, Holicek, Peter, Salek, Cyril, Hensler, Michal, Kasikova, Lenka, Pasulka, Josef, Holubova, Monika, Kovar, Marek, Lysak, Daniel, Kline, Justin P., Racil, Zdenek, Galluzzi, Lorenzo, Spisek, Radek, Fucikova, Jitka
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2021
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946028/
https://ncbi.nlm.nih.gov/pubmed/33758676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2021.1889822
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