Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport

BACKGROUND: Impaired axonal transport may contribute to the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD) and Down syndrome (DS). Axonal transport is a complex process in which specific motor proteins move cargoes to and from neuronal cell bodies and their processes....

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Bibliographic Details
Published in:Alzheimers Res Ther
Main Authors: Chen, Xu-Qiao, Das, Utpal, Park, Gooho, Mobley, William C.
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7945332/
https://ncbi.nlm.nih.gov/pubmed/33691783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-021-00796-6
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