High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3

BACKGROUND: Oxidative stress is a common cause of neurodegeneration and plays a central role in retinal degenerative diseases. Heme oxygenase-1 (HMOX1) is a redox-regulated enzyme that is induced in neurodegenerative diseases and acts against oxidative stress but can also promote cell death, a pheno...

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Pubblicato in:Mol Neurodegener
Autori principali: Li, Huirong, Liu, Bo, Lian, Lili, Zhou, Jiajia, Xiang, Shengjin, Zhai, Yifan, Chen, Yu, Ma, Xiaoyin, Wu, Wencan, Hou, Ling
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7944639/
https://ncbi.nlm.nih.gov/pubmed/33691741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00437-4
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