Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation

The degradation of p53 is a hallmark of high-risk human papillomaviruses (HPVs) of the alpha genus and HPV-related carcinogenicity. The oncoprotein E6 forms a ternary complex with the E3 ubiquitin ligase E6-associated protein (E6AP) and tumor suppressor protein p53 targeting p53 for ubiquitination....

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Conrady, Marcel Chris, Suarez, Irina, Gogl, Gergö, Frecot, Desiree Isabella, Bonhoure, Anna, Kostmann, Camille, Cousido-Siah, Alexandra, Mitschler, André, Lim, JiaWen, Masson, Murielle, Iftner, Thomas, Stubenrauch, Frank, Travé, Gilles, Simon, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7944444/
https://ncbi.nlm.nih.gov/pubmed/33115863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00730-20
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