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ALS2 regulates endosomal trafficking, postsynaptic development, and neuronal survival
Mutations in the human ALS2 gene cause recessive juvenile-onset amyotrophic lateral sclerosis and related motor neuron diseases. Although the ALS2 protein has been identified as a guanine-nucleotide exchange factor for the small GTPase Rab5, its physiological roles remain largely unknown. Here, we d...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7944400/ https://ncbi.nlm.nih.gov/pubmed/33683284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202007112 |
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