Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition

Severe renal fibrosis often occurs in obstructive kidney disease, not only in the obstructed kidney but also in the contralateral kidney, causing renal dysfunction. Although the mechanisms of injury in obstructed kidney have been studied for years, the pathogenesis of fibrosis in the contralateral k...

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Vydáno v:Front Pharmacol
Hlavní autoři: Xiong, Yunzhao, Chang, Yi, Hao, Juan, Zhang, Cuijuan, Yang, Fan, Wang, Zheng, Liu, Yunmeng, Wang, Xiangting, Mu, Shengyu, Xu, Qingyou
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943730/
https://ncbi.nlm.nih.gov/pubmed/33716747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.620433
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