Cell-Free DNA Promotes Thrombin Autolysis and Generation of Thrombin-Derived C-Terminal Fragments

Cell-free DNA (cfDNA) is the major structural component of neutrophil extracellular traps (NETs), an innate immune response to infection. Antimicrobial proteins and peptides bound to cfDNA play a critical role in the bactericidal property of NETs. Recent studies have shown that NETs have procoagulan...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Saravanan, Rathi, Choong, Yeu Khai, Lim, Chun Hwee, Lim, Li Ming, Petrlova, Jitka, Schmidtchen, Artur
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943729/
https://ncbi.nlm.nih.gov/pubmed/33717072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.593020
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