Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides

Thrombin-derived C-terminal peptides (TCPs) of about 2 kDa are present in wounds, where they exert anti-endotoxic functions. Employing a combination of nuclear magnetic resonance spectroscopy (NMR), biophysical, mass spectrometry and cellular studies combined with in silico multiscale modelling, we...

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Publicado no:Nat Commun
Main Authors: Saravanan, Rathi, Holdbrook, Daniel A, Petrlova, Jitka, Singh, Shalini, Berglund, Nils A, Choong, Yeu Khai, Kjellström, Sven, Bond, Peter J, Malmsten, Martin, Schmidtchen, Artur
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050251/
https://ncbi.nlm.nih.gov/pubmed/30018388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05242-0
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