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Structural resolution of switchable states of a de novo peptide assembly

De novo protein design is advancing rapidly. However, most designs are for single states. Here we report a de novo designed peptide that forms multiple α-helical-bundle states that are accessible and interconvertible under the same conditions. Usually in such designs amphipathic α helices associate...

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Pubblicato in:Nat Commun
Autori principali: Dawson, William M., Lang, Eric J. M., Rhys, Guto G., Shelley, Kathryn L., Williams, Christopher, Brady, R. Leo, Crump, Matthew P., Mulholland, Adrian J., Woolfson, Derek N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943578/
https://ncbi.nlm.nih.gov/pubmed/33750792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21851-8
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