Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations

Mutations in the human CSF1R gene have been associated with dominant and recessive forms of neurodegenerative disease. Here we describe the impacts of Csf1r mutation in the rat on development of the brain. Diffusion imaging indicated small reductions in major fiber tracts that may be associated in p...

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Publicat a:Neurobiol Dis
Autors principals: Patkar, Omkar L., Caruso, Melanie, Teakle, Ngari, Keshvari, Sahar, Bush, Stephen J., Pridans, Clare, Belmer, Arnauld, Summers, Kim M., Irvine, Katharine M., Hume, David A.
Format: Artigo
Idioma:Inglês
Publicat: Academic Press 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941205/
https://ncbi.nlm.nih.gov/pubmed/33450391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2021.105268
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