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Designed whole-cell-catalysis-assisted synthesis of 9,11-secosterols
A method for the synthesis of 9,11-secosteroids starting from the natural corticosteroid cortisol is described. There are two key steps in this approach, combining chemistry and synthetic biology. Stereo- and regioselective hydroxylation at C9 (steroid numbering) is carried out using whole-cell bioc...
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| Udgivet i: | Beilstein J Org Chem |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Beilstein-Institut
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7940815/ https://ncbi.nlm.nih.gov/pubmed/33747232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.17.52 |
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