The Reality of Randomized Controlled Trials for Assessing the Benefit of Proton Therapy: Critically Examining the Intent-to-Treat Principle in the Presence of Insurance Denial

PURPOSE: This study hypothesized that insurance denial would lead to bias and loss of statistical power when evaluating the results from an intent-to-treat (ITT), per-protocol, and as-treated analyses using a simulated randomized clinical trial comparing proton therapy to intensity modulated radiati...

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Detaylı Bibliyografya
Yayımlandı:Adv Radiat Oncol
Asıl Yazarlar: Hernandez, Mike, Lee, J. Jack, Yeap, Beow Y., Ye, Rong, Foote, Robert L., Busse, Paul, Patel, Samir H., Dagan, Roi, Snider, James, Mohammed, Nasiruddin, Lin, Alexander, Blanchard, Pierre, Cantor, Scott B., Teferra, Menna Y., Hutcheson, Kate, Yepes, Pablo, Mohan, Radhe, Liao, Zhongxing, DeLaney, Thomas F., Frank, Steven J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2020
Konular:
Critical Review
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940795/
https://ncbi.nlm.nih.gov/pubmed/33732960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.adro.2020.100635
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