The Reality of Randomized Controlled Trials for Assessing the Benefit of Proton Therapy: Critically Examining the Intent-to-Treat Principle in the Presence of Insurance Denial

PURPOSE: This study hypothesized that insurance denial would lead to bias and loss of statistical power when evaluating the results from an intent-to-treat (ITT), per-protocol, and as-treated analyses using a simulated randomized clinical trial comparing proton therapy to intensity modulated radiati...

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Detalhes bibliográficos
Publicado no:Adv Radiat Oncol
Main Authors: Hernandez, Mike, Lee, J. Jack, Yeap, Beow Y., Ye, Rong, Foote, Robert L., Busse, Paul, Patel, Samir H., Dagan, Roi, Snider, James, Mohammed, Nasiruddin, Lin, Alexander, Blanchard, Pierre, Cantor, Scott B., Teferra, Menna Y., Hutcheson, Kate, Yepes, Pablo, Mohan, Radhe, Liao, Zhongxing, DeLaney, Thomas F., Frank, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Critical Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940795/
https://ncbi.nlm.nih.gov/pubmed/33732960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.adro.2020.100635
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