Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo

Whooping cough is caused by Bordetella pertussis that releases pertussis toxin (PT) which comprises enzyme A-subunit PTS1 and binding/transport B-subunit. After receptor-mediated endocytosis, PT reaches the endoplasmic reticulum from where unfolded PTS1 is transported to the cytosol. PTS1 ADP-ribosy...

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Publicado no:Sci Rep
Main Authors: Ernst, Katharina, Mittler, Ann-Katrin, Winkelmann, Veronika, Kling, Carolin, Eberhardt, Nina, Anastasia, Anna, Sonnabend, Michael, Lochbaum, Robin, Wirsching, Jan, Sakari, Moona, Pulliainen, Arto T., Skerry, Ciaran, Carbonetti, Nicholas H., Frick, Manfred, Barth, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940712/
https://ncbi.nlm.nih.gov/pubmed/33686161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84817-2
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