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CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology
Inducible conditional knockout mice are important tools for studying gene function and disease therapy, but their generation is costly and time-consuming. We introduced clustered regularly interspaced short palindromic repeats (CRISPR) and Cre into an LSL-Cas9 transgene-carrying mouse line by using...
Zapisane w:
| Wydane w: | Mol Ther Methods Clin Dev |
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| Główni autorzy: | , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society of Gene & Cell Therapy
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7940702/ https://ncbi.nlm.nih.gov/pubmed/33738329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.02.012 |
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