CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology

Inducible conditional knockout mice are important tools for studying gene function and disease therapy, but their generation is costly and time-consuming. We introduced clustered regularly interspaced short palindromic repeats (CRISPR) and Cre into an LSL-Cas9 transgene-carrying mouse line by using...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Xiao, Dan, Zhang, Weifeng, Wang, Qing, Li, Xing, Zhang, Yuan, Rasouli, Javad, Casella, Giacomo, Ciric, Bogoljub, Curtis, Mark, Rostami, Abdolmohamad, Zhang, Guang-Xian
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2021
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940702/
https://ncbi.nlm.nih.gov/pubmed/33738329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.02.012
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