Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors

It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little is known about how BRCA1 loss-of-function (LOF) and concomitant mutations affect th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bach, Karsten, Pensa, Sara, Zarocsinceva, Marija, Kania, Katarzyna, Stockis, Julie, Pinaud, Silvain, Lazarus, Kyren A., Shehata, Mona, Simões, Bruno M., Greenhalgh, Alice R., Howell, Sacha J., Clarke, Robert B., Caldas, Carlos, Halim, Timotheus Y. F., Marioni, John C., Khaled, Walid T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940427/
https://ncbi.nlm.nih.gov/pubmed/33686070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21783-3
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados