HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

Brain homeostasis is regulated by the viability and functionality of neurons. HAT (histone acetyltransferase) and HDAC (histone deacetylase) inhibitors have been applied to treat neurological deficits in humans; yet, the epigenetic regulation in neurodegeneration remains elusive. Mutations of HAT co...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Tapias, Alicia, Lázaro, David, Yin, Bo-Kun, Rasa, Seyed Mohammad Mahdi, Krepelova, Anna, Kelmer Sacramento, Erika, Grigaravicius, Paulius, Koch, Philipp, Kirkpatrick, Joanna, Ori, Alessandro, Neri, Francesco, Wang, Zhao-Qi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2021
Pynciau:
Chromosomes and Gene Expression
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939550/
https://ncbi.nlm.nih.gov/pubmed/33594975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61531
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