HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

Brain homeostasis is regulated by the viability and functionality of neurons. HAT (histone acetyltransferase) and HDAC (histone deacetylase) inhibitors have been applied to treat neurological deficits in humans; yet, the epigenetic regulation in neurodegeneration remains elusive. Mutations of HAT co...

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Udgivet i:eLife
Main Authors: Tapias, Alicia, Lázaro, David, Yin, Bo-Kun, Rasa, Seyed Mohammad Mahdi, Krepelova, Anna, Kelmer Sacramento, Erika, Grigaravicius, Paulius, Koch, Philipp, Kirkpatrick, Joanna, Ori, Alessandro, Neri, Francesco, Wang, Zhao-Qi
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2021
Fag:
Chromosomes and Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939550/
https://ncbi.nlm.nih.gov/pubmed/33594975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61531
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