Characterization of clonal evolution in microsatellite unstable metastatic cancers through multi-regional tumor sequencing

Microsatellites are short, repetitive segments of DNA, which are dysregulated in mismatch repair-deficient (MMRd) tumors resulting in microsatellite instability (MSI). MSI has been identified in many human cancer types with varying incidence, and microsatellite instability-high (MSI-H) tumors often...

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Vydáno v:Mol Cancer Res
Hlavní autoři: Bonneville, Russell, Paruchuri, Anoosha, Wing, Michele R., Krook, Melanie A., Reeser, Julie W., Chen, Hui-Zi, Dao, Thuy, Samorodnitsky, Eric, Smith, Amy M., Yu, Lianbo, Nowacki, Nicholas, Chen, Wei, Roychowdhury, Sameek
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939074/
https://ncbi.nlm.nih.gov/pubmed/33229401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0955
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