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Recapitulating pancreatic tumor microenvironment through synergistic use of patient organoids and organ-on-a-chip vasculature

Tumor progression relies heavily on the interaction between the neoplastic epithelial cells and their surrounding stromal partners. This cell cross-talk affects stromal development, and ultimately the heterogeneity impacts drug efflux and efficacy. To mimic this evolving paradigm, we have micro-engi...

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Detalhes bibliográficos
Publicado no:Adv Funct Mater
Main Authors: Lai Benjamin, F. L., Lu Rick, X., Hu, Yangshuo, Davenport, Huyer Locke, Dou, Wenkun, Wang, Erika Y., Radulovich, Nikolina, Tsao, Ming S., Sun, Yu, Radisic, Milica
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939064/
https://ncbi.nlm.nih.gov/pubmed/33692660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adfm.202000545
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