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Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
Functional diversity of the highly polymorphic human leukocyte antigen class I (HLA-I) genes underlies successful immunologic control of both infectious disease and cancer. The divergent allele advantage hypothesis dictates that an HLA-I genotype with two alleles with sequences that are more diverge...
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| Publicado no: | Nat Med |
|---|---|
| Principais autores: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7938381/ https://ncbi.nlm.nih.gov/pubmed/31700181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0639-4 |
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