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Single-Base Resolution: Increasing the Specificity of the CRISPR-Cas System in Gene Editing
The CRISPR-Cas system holds great promise in the treatment of diseases caused by genetic variations. The Cas protein, an RNA-guided programmable nuclease, generates a double-strand break at precise genomic loci. However, the use of the clustered regularly interspersed short palindromic repeats (CRIS...
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| Publicado en: | Mol Ther |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Gene & Cell Therapy
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7938333/ https://ncbi.nlm.nih.gov/pubmed/33248248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.11.009 |
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