Structure of a type IV CRISPR-Cas ribonucleoprotein complex

We reveal the cryo-electron microscopy structure of a type IV-B CRISPR ribonucleoprotein (RNP) complex (Csf) at 3.9-Å resolution. The complex best resembles the type III-A CRISPR Csm effector complex, consisting of a Cas7-like (Csf2) filament intertwined with a small subunit (Cas11) filament, but th...

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Bibliografske podrobnosti
izdano v:iScience
Main Authors: Zhou, Yi, Bravo, Jack P.K., Taylor, Hannah N., Steens, Jurre A., Jackson, Ryan N., Staals, Raymond H.J., Taylor, David W.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7937560/
https://ncbi.nlm.nih.gov/pubmed/33733066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102201
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