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Intestinal Efflux Transporters P-gp and BCRP Are Not Clinically Relevant in Apixaban Disposition

PURPOSE: The involvement of the intestinally expressed xenobiotic transporters P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) have been implicated in apixaban disposition based on in vitro studies. Recommendations against co-administration of apixaban with inhibitors of these effl...

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Udgivet i:Pharm Res
Main Authors: Sodhi, Jasleen K., Liu, Shuaibing, Benet, Leslie Z.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936879/
https://ncbi.nlm.nih.gov/pubmed/32996065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-020-02927-4
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