Hybrid Nanoparticles Modified by Hyaluronic Acid Loading an HSP90 Inhibitor as a Novel Delivery System for Subcutaneous and Orthotopic Colon Cancer Therapy

BACKGROUND: As a therapeutic target for cancer treatment, HSP90 has been explored extensively. However, the significant side effects of the HSP90 inhibitor 17AAG have limited its clinical use. METHODS: In this study, we used hyaluronic acid (HA)–decorated DOTAP–PLGA hybrid nanoparticles (HA-DOTAP-PL...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Pan, Chenwei, Zhang, Tiaotiao, Li, Shaoxun, Xu, Zhihua, Pan, Binhui, Xu, Sheng, Jin, Shuanghong, Lu, Guangrong, Yang, Shouxing, Xue, Zhanxiong, Chen, Ping, Shen, Xian, Wang, Fangyan, Xu, Changlong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2021
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936682/
https://ncbi.nlm.nih.gov/pubmed/33688189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S275805
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